Anti-Inflammatory Activity of Cinnamon Bark Oil (Cinnamomum burmannii (Nees & T. Nees) Blume from Lombok Timur Indonesia

Introduction: Research related to alternative medicine from natural ingredients that can relieve the effects of inflammation is important, especially reduce unwanted side antiinflammatory drugs. Cinnamomum burmannii (Nees & T. Nees) Blume a native Indonesian species which contains essential oils and reported for its anti-inflammatory effect. Therefore, this research was conducted determine metabolite profile effect oil bark C. (CBO) Lombok Timur Regency. Methods: The CBO determined using Gas Chromatography-Mass Spectra (GCMS). test used male Wistar rats. A total 30 rats were divided into 5 groups, each group consisting 6 Rats injected with carrageenan 1%/100μl/paw had previously been given oral at dose 30, 60, 90 mg/kg BW. Paw swelling measured 1, 2, 3, 4 hours after injection. volume edema animals sacrificed. left leg cut preserved as material Hematoxylin Eosin (HE) Immunohistochemistry (IHC) preparations. variables taken percentage inhibition edema, number inflammatory cells by HE amount TNF-α IHC staining. Results: results showed there difference between negative control positive in observed rat’s paw edema. less control. Likewise, when administering (60 BW BW) lower than Conclusion: It be concluded agent.